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Audit Trail Software

Audit trail software for pharma, biotech and GxP-regulated manufacturing

A GxP audit trail is not a log file. It is inspection evidence — and inspectors know when it has been retrofitted. cGen's audit trail is designed from the first record as tamper-evident, cryptographically signed, and periodically reviewable, because that is what Part 11, Annex 11 and GAMP 5 all now require.

Append-only, cryptographically signed

Every entry is signed with a hash chain; any tampering breaks the chain and is visible on the next verification pass.

Periodic review workflow

Annex 11 §9 requires periodic audit-trail review by an authorised person. cGen produces the review queue, tracks the reviewers, and archives the sign-off.

Exportable for inspection

Inspector Mode gives auditors a scoped, time-limited, watermarked view of the audit trail — filtered by system, user, date range, or record type.

What GxP audit trail software must record

The audit-trail requirement is deceptively simple: capture what changed, who changed it, when, and why. In practice, the failure mode is almost always the same — the "why" is missing because the software did not force a reason-for-change entry at the point of edit.

For every controlled record in a GxP system, the audit trail must record the create/modify/delete event, the identity of the actor (uniquely attributable), the timestamp (contemporaneous, synchronised to a trusted time source), the old value and new value for edits, and an operator-supplied reason for the change. Deletes should be logical (with retention) rather than physical.

What cGen's audit trail captures

  • Create/modify/delete event on every controlled record
  • Actor identity, uniquely attributable, verified against a live directory
  • Contemporaneous timestamp synchronised to NTP
  • Old value / new value on every edit
  • Mandatory reason-for-change entry — the record cannot be saved without it
  • Signature hash on every entry; hash-chained forward and back
  • Verification job that periodically re-hashes and confirms the chain is intact
  • Periodic review workflow with authorised reviewer, sign-off, and archive
  • Signed PDF export of any date-range or per-record audit trail slice

How cGen fits

Built for this exact problem

cGen's audit trail is not an afterthought or a downloadable log. It is the substrate of every controlled record in the platform, and it is one of the most-quoted reasons customers switched from legacy CSV tools where the audit trail was a feature bolted onto a document-management system.

FAQ

Audit Trail Software — frequently asked questions

Part 11 §11.10(e) requires computer-generated audit trails that record operator entries and actions that create, modify, or delete records — with the audit trail retained for at least as long as the underlying record.
cGen

cGen — AI-native computer system validation software for life sciences. Design, validate, and continuously monitor your GxP-regulated systems in one inspection-ready environment.

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21 CFR Part 11 GAMP 5 SOC 2 Type II EU GMP Annex 11

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